Serena Williams lowered the curtains during her weight loss journey and revealed that she has been using Zepbough injections since early 2024 to help give birth to her second daughter, Adira.
The 23-time Grand Slam champion told people that despite insisting on strict exercise and nutritional habits, she turned to medication after working hard to lose weight after working hard.
“No matter how much training I did, I couldn’t reflect the weight I needed,” she said. “It was crazy because I’ve never been to a place like this, and in my life I worked hard and ate so healthy that I could never get to where I needed to.”
Williams, 43, said her weight concerns began with her first daughter, Alexis Olympia, in 2017.
“I always get to a certain level on scale, but I can never get below that. That’s when I decided it’s time to try something different and use GLP-1 with RO,” she told Vogue.
Williams has lost 31 pounds since his injections once a week. The GLP-1 receptor agonist Zepbound is usually prescribed for type 2 diabetes, but it is becoming increasingly popular in weight management.
The drug received an FDA-approved weight loss in late 2023.
Williams stressed that the drug did not replace her healthy lifestyle. She continued to exercise and eat clean, thanks to the injection to help her break through smoothly.
“I feel my old self,” she said, adding that she feels “sexier” and “more confident.”
Williams wants to expect her transformation, saying she openly challenged criticism surrounding GLP-1 drugs.
“I think a lot of people have this stigma about GLP-1 and then say ‘Oh, lazy people do’, or ‘If you work hard, you don’t need that,'” she said. “From my experience, I know that this is not true at all. Sometimes you need help.”
Williams, now serving as celebrity patient ambassador for prescription telemedicine company RO RO, Williams appears in a new campaign where she will inject her shots on camera.
Her partnership with RO began after she completed her breastfeeding Adira in early 2024.

